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An excipient is used to produce fast-dissolving tablet forms. To achieve the desired efficiency, this excipient is thinned to below 70 microns. It is sieved and used as an excipient within the tablet.
What is the Importance of Fast-Dissolving Tablets?
Some people find it difficult to swallow medications taken by the oral route. This may be because these individuals have insufficient chewing and swallowing abilities. For these reasons, having tablets that disintegrate rapidly and dissolve quickly is of great importance.
For tablets to have rapid solubility, it is essential for them to have a porous structure. And the pores in the tablet must be sufficient in number. At the same time, integrity must be ensured.
In some research, costs are slightly higher due to process conditions in tablets where a solvent is used. In this application, the solvent is evaporated.
In another tablet formula, a cold press method is applied to create a porous structure. In this application, a porous structure is created by filling. The solvent here is evaporated under vacuum.
The tablet we obtain is in a form that disintegrates very quickly in the mouth in the presence of water and helps swallowing without difficulty.
What is the Fast-Dissolving Tablet Formula?
One or more carbohydrates are used in the tablet formula to be produced. A polymer is used to increase the strength of the resulting tablet. Ammonium Bicarbonate is used to create a porous structure within the tablet. A flavoring agent with taste-masking properties.
Carbohydrates in the tablet are selected from the following substances.
While these carbohydrates affect the strength of the resulting tablet form, they also help in making significant changes to its taste.
In this application, combinations obtained with powder sorbitol and lactose are the forms that best affect the dissolution of the resulting tablet. The percentage of this mixture in the tablet is between 15% and 20%. Sorbitol is used to modify the taste of the tablet. Lactose has the property of increasing the dissolution of the tablet. Mannitol can be used instead of lactose. However, using mannitol will cause a slowdown in the dissolution rate. The strength of this tablet can be increased by adding some maltodextrin to the tablet form.
What is the Composition of Fast-Dissolving Porous Tablets?
The formula of the composition is as follows.
Water-soluble polymers used in fast-dissolving porous tablets are used to control the dissolution rate of the tablet. These polymers ensure the rapid disintegration of the tablet and the release of the drug. For example, substances such as hydroxypropyl methyl cellulose (HPMC) and polyvinyl pyrrolidone (PVP) can be used.
